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Description
Biotinylated LILRB4/CD85K/ILT3 Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms LIR5,HM18,ILT 3 Accession Q8NHJ6 Amino Acid Sequence Gln22 Glu259 with hIgG1 Fc&Avi Tag at the C Terminus Expression System HEK293 Molecular Weight 55 70kDa (Reducing) Purity 95% by SDS PAGE & > 95% RP HPLC Conjugation Biotin Tag Avi Tag, Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Human |
| Synonyms | LIR5,HM18,ILT-3 |
| Accession | Q8NHJ6 |
| Amino Acid Sequence | Gln22-Glu259 with hIgG1 Fc&Avi Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 55-70kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 95% RP-HPLC |
| Conjugation | Biotin |
| Tag | Avi Tag, Human IgG1 Fc |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Zhou Y, Li Y, He Q, Kong Z, Yu R, Yu X, Xie A. Uncovering the Associations of LILRB4 Genotypes With Parkinson's Disease: From Clinical Traits to Potential Pathologies. CNS Neurosci Ther. 2025 Jul;31(7):e70522. |
Background
ILT3 (also known as LILRB4/CD85k/LIR-5) is an approximately 60 kDa transmembrane glycoprotein containing two immunoglobulin-like domains in its extracellular region and three ITIM inhibitory motifs in its intracellular region, with a secreted isoform detectable in serum. This protein is primarily expressed in myeloid cells such as monocytes and dendritic cells, as well as vascular endothelial cells. By recognizing MHC class I molecules and transmitting inhibitory signals, it negatively regulates immune cell activation and can induce the generation of CD8⁺ suppressor T cells, thereby promoting immune tolerance. Clinically, ILT3 is involved in suppressing transplant rejection, while the upregulation of its soluble form in the tumor microenvironment is associated with immune evasion, making it a potential target for immunotherapy.
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