BM Hyal Injection : Intra-articular Hyaluronic Acid Injection for Knee Osteoarthritis & Periarthritis of the shoulder

BM Hyal Injection : Intra-articular Hyaluronic Acid Injection for Knee Osteoarthritis & Periarthritis of the shoulderProduct Overview BM Hyal Injection is a sterile, viscoelastic solution of hyaluronic acid designed for intra articular administration. It helps relieve pain and improve joint mobility in patients with knee osteoarthritis or periarthritis of the shoulder by supplementing the synovial fluid and protecting the cartilage. Indications Knee osteoarthritis Periarthritis of the shoulder Dosage & Administration Adults: Inject one vial (one pre filled syringe)

Product Overview

BM Hyal Injection is a sterile, viscoelastic solution of hyaluronic acid designed for intra-articular administration.
It helps relieve pain and improve joint mobility in patients with knee osteoarthritis or periarthritis of the shoulder by supplementing the synovial fluid and protecting the cartilage.

Indications

• Knee osteoarthritis

• Periarthritis of the shoulder

Dosage & Administration

• Adults: Inject one vial (one pre-filled syringe) into the affected joint once a week for 3 consecutive weeks.

• The dosage and frequency can be adjusted by the physician depending on the patient’s condition and response.

• Administer intra-articularly into the knee or shoulder joint cavity under strict aseptic conditions.

• If no improvement is observed after three injections, treatment should be discontinued.

Important Notes

Because BM Hyal is administered directly into the joint, it must be performed under strict aseptic technique by a healthcare professional.

Precautions

Contraindications

Do not administer to:

• Patients with known hypersensitivity to hyaluronic acid or any component of the formulation.

Use with Caution in:

• Patients with a history of hypersensitivity to other medications.

• Patients with liver disorders or a history thereof (cases of elevated AST/ALT have been reported).

• Patients with skin disease or infection at the injection site.

Adverse Reactions

Serious

• Shock: Rare but possible. Patients should be monitored closely during and after the procedure. Discontinue immediately if symptoms occur and provide appropriate treatment.

Others

• Hypersensitivity: Facial or eyelid edema, facial flushing, rash, urticaria, pruritus.

• Injection site reactions: Transient pain, swelling, mild effusion, redness, warmth, severe localized pressure sensation.

• Others: Nausea, vomiting, fever.

General Precautions

• If the joint has severe inflammation due to osteoarthritis, treat the inflammation first before administering BM Hyal.

• To avoid exacerbating local pain, advise the patient to rest the joint after injection.

• Ensure the injection is properly delivered into the joint cavity to prevent extra-articular pain.

• Do not inject into blood vessels or use for ophthalmic purposes.

• Avoid contact with disinfectants containing benzalkonium chloride, quaternary ammonium salts, or chlorhexidine as precipitation may occur.

Special Populations

• Pregnancy & Lactation: Animal studies did not show teratogenic effects, but use only if the potential benefit justifies the potential risk. Hyaluronic acid may pass into breast milk; breastfeeding should be avoided during treatment.

• Children: Safety and efficacy in pediatric patients have not been established.

• Elderly: Use with caution as physiological functions may be reduced.

Administration Notes

• Use a 22–23G needle for injection.

• If joint effusion is present, aspirate the fluid before injection.

• Administer strictly intra-articularly — not intravenously or subcutaneously.

• If no symptom improvement is observed after three injections, discontinue treatment.